Theory and Applications of the Transferred Nuclear Overhauser Effect to the Study of the Conformations of Small Ligands Bound to Proteins

@inproceedings{MKaysera2004TheoryAA,
  title={Theory and Applications of the Transferred Nuclear Overhauser Effect to the Study of the Conformations of Small Ligands Bound to Proteins},
  author={G. M.Kaysera. and CLOREAND and M. A.. and GRONENBORN},
  year={2004}
}
The principles, theory, and applications of the transferred proton-proton nuclear Overhauser effect (TRNOE) to the study of the conformations of small molecules to proteins are presented and discussed. The basis of the TRNOE involves the transfer of information concerning cross relaxation between two bound ligand nuclei from the bound to the free state by chemical exchange so that negative NOES on the easily detectable free or observed ligand resonances may be seen following irradiation of… CONTINUE READING

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