Theories of biological aging: Genes, proteins, and free radicals

@article{Rattan2006TheoriesOB,
  title={Theories of biological aging: Genes, proteins, and free radicals},
  author={S. Rattan},
  journal={Free Radical Research},
  year={2006},
  volume={40},
  pages={1230 - 1238}
}
  • S. Rattan
  • Published 2006
  • Biology, Medicine
  • Free Radical Research
  • Traditional categorization of theories of aging into programmed and stochastic ones is outdated and obsolete. Biological aging is considered to occur mainly during the period of survival beyond the natural or essential lifespan (ELS) in Darwinian terms. Organisms survive to achieve ELS by virtue of genetically determined longevity assuring maintenance and repair systems (MRS). Aging at the molecular level is characterized by the progressive accumulation of molecular damage caused by… CONTINUE READING
    312 Citations

    Topics from this paper.

    Paper Mentions

    The Science of Healthy Aging
    • S. Rattan
    • Biology, Medicine
    • Annals of the New York Academy of Sciences
    • 2007
    • 22
    Molecular and Cellular Basis of Aging
    • 3
    Biology of ageing: principles, challenges and perspectives.
    • S. Rattan
    • Biology, Medicine
    • Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    • 2015
    • 15
    • PDF
    Increased molecular damage and heterogeneity as the basis of aging
    • S. Rattan
    • Biology, Medicine
    • Biological chemistry
    • 2008
    • 112
    Current View on Biology of Aging
    • 1
    Hormesis in aging
    • S. Rattan
    • Biology, Medicine
    • Ageing Research Reviews
    • 2008
    • 367
    • PDF
    Programmatic features of aging originating in development: aging mechanisms beyond molecular damage?
    • J. P. de Magalhaes
    • Medicine
    • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
    • 2012
    • 30
    • PDF
    When a theory of aging ages badly
    • 240
    • PDF

    References

    SHOWING 1-10 OF 123 REFERENCES
    Understanding and Modulating Ageing
    • 53
    Free Radical Theory of Aging: An Update
    • D. Harman
    • Biology, Medicine
    • Annals of the New York Academy of Sciences
    • 2006
    • 486
    Evolution of ageing
    • T. Kirkwood
    • Biology, Medicine
    • Mechanisms of Ageing and Development
    • 2002
    • 656
    Aging intervention, prevention, and therapy through hormesis.
    • S. Rattan
    • Medicine
    • The journals of gerontology. Series A, Biological sciences and medical sciences
    • 2004
    • 108
    • PDF
    Understanding ageing.
    • R. Holliday
    • Medicine
    • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
    • 1997
    • 146
    • Highly Influential
    • PDF
    The Nature of Gerontogenes and Vitagenes: Antiaging Effects of Repeated Heat Shock on Human Fibroblasts
    • S. Rattan
    • Medicine, Biology
    • Annals of the New York Academy of Sciences
    • 1998
    • 42
    Aging is No Longer an Unsolved Problem in Biology
    • R. Holliday
    • Biology, Medicine
    • Annals of the New York Academy of Sciences
    • 2006
    • 137
    • Highly Influential
    • PDF
    Impairment of proteasome structure and function in aging.
    • 284