Theories of biological aging: Genes, proteins, and free radicals

  title={Theories of biological aging: Genes, proteins, and free radicals},
  author={S. Rattan},
  journal={Free Radical Research},
  pages={1230 - 1238}
  • S. Rattan
  • Published 2006
  • Medicine, Biology
  • Free Radical Research
  • Traditional categorization of theories of aging into programmed and stochastic ones is outdated and obsolete. Biological aging is considered to occur mainly during the period of survival beyond the natural or essential lifespan (ELS) in Darwinian terms. Organisms survive to achieve ELS by virtue of genetically determined longevity assuring maintenance and repair systems (MRS). Aging at the molecular level is characterized by the progressive accumulation of molecular damage caused by… CONTINUE READING

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    Publications referenced by this paper.
    Free Radical Theory of Aging: An Update
    • 479
    Evolution of ageing
    • 645
    The Plasticity of Aging: Insights from Long-Lived Mutants
    • 1,199
    • PDF
    Understanding and Modulating Ageing
    • 53
    Fractal dynamics in physiology: Alterations with disease and aging
    • 1,672
    • PDF
    Understanding ageing.
    • 143
    • Highly Influential
    • PDF
    Aging intervention, prevention, and therapy through hormesis.
    • 109
    • PDF