Theories of biological aging: Genes, proteins, and free radicals
@article{Rattan2006TheoriesOB,
title={Theories of biological aging: Genes, proteins, and free radicals},
author={S. Rattan},
journal={Free Radical Research},
year={2006},
volume={40},
pages={1230 - 1238}
}Traditional categorization of theories of aging into programmed and stochastic ones is outdated and obsolete. Biological aging is considered to occur mainly during the period of survival beyond the natural or essential lifespan (ELS) in Darwinian terms. Organisms survive to achieve ELS by virtue of genetically determined longevity assuring maintenance and repair systems (MRS). Aging at the molecular level is characterized by the progressive accumulation of molecular damage caused by… Expand
Topics from this paper
327 Citations
The Science of Healthy Aging
- Biology, Medicine
- Annals of the New York Academy of Sciences
- 2007
The genetic processes of MRSs operate in a complex hierarchy of factors which range from intracellular molecular factors to physiological, psychological, environmental, and other stochastic factors, including chance. Expand
Molecular and Cellular Basis of Aging
- Biology
- 2016
Mild stress-induced hormesis caused by physical, biological, and nutritional hormetins is a promising holistic strategy for strengthening the homeodynamics. Expand
Biology of ageing: principles, challenges and perspectives.
- Biology, Medicine
- Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
- 2015
Wholistic methods incorporating lifestyle-based hormetic interventions, including food, physical activity and mental engagement, appear to be potentially more successful in maintaining health and in extending healthspan and longevity. Expand
Increased molecular damage and heterogeneity as the basis of aging
- Biology, Medicine
- Biological chemistry
- 2008
Mild stress-induced hormesis by physical, biological and nutritional methods, including hormetins, represents a promising strategy for achieving healthy aging and for preventing age-related diseases. Expand
Current View on Biology of Aging
- Biology
- 2010
Biomarkers of aging, as in senescence marker protein-30 and klotho protein, offer the feasibility for exploring aging biology and physiology, advancing the understanding of genetic and lifestyle contributions to aging, and, at best, developing effective age-defying interventions. Expand
Molecular Gerontology: Principles and Perspectives for Interventions
- Biology
- 2014
Novel approaches for testing and developing effective means of intervention, prevention, and modulation of aging incorporate means to minimize the occurrence and accumulation of molecular damage, and to strengthen the homeodynamics of the organism. Expand
Hormesis in aging
- Biology, Medicine
- Ageing Research Reviews
- 2008
Hormesis in aging is represented by mild stress-induced stimulation of protective mechanisms in cells and organisms resulting in biologically beneficial effects that counter-balances the progressive shrinkage of the homeodynamic space, which is the ultimate cause of aging, diseases and death. Expand
Programmatic features of aging originating in development: aging mechanisms beyond molecular damage?
- Medicine
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology
- 2012
Overall, it appears that the genome does, indeed, contain specific instructions that drive aging in animals, a radical shift in the authors' perception of the aging process. Expand
Oxidative stress and aging: the potential role of iron
- Medicine
- Hormones
- 2008
It is proposed that the availability of intracellular iron in its redox active form (labile iron) represents the main catalyst that mediates extensive oxidative modifications of cellular components and ultimately leads to their accumulation and consequent cellular dysfunction. Expand
Programmatic features of aging originating in development: aging mechanisms beyond molecular damage?
- Biology
- 2012
Overall, it appears that the genome does, indeed, contain specific instructions that drive aging in animals, a radical shift in the authors' perception of the aging process. Expand
References
SHOWING 1-10 OF 123 REFERENCES
Understanding and Modulating Ageing
- Biology, Medicine
- IUBMB life
- 2005
A combination of molecular, physiological and psychological modulatory approaches can realize “healthy ageing” as an achievable goal in the not‐so‐distant future. Expand
Free Radical Production and Antioxidant Defense: A Primer
- Chemistry
- 2003
Aging is the progressive accumulation of changes over time that increases the probability of disease and death. There is good reason to believe that molecular damage, and the limited ability of… Expand
Free Radical Theory of Aging: An Update
- Biology, Medicine
- Annals of the New York Academy of Sciences
- 2006
The extensive studies based on the FRTA hold promise thatALE‐B and the MLS can be extended, the ALE‐B possibly by a few years, and theMLS somewhat less. Expand
Evolution of ageing
- Biology, Medicine
- Mechanisms of Ageing and Development
- 2002
To make progress in understanding the role and evolution of genetic and non-genetic factors in human longevity, more detailed theoretical studies of how intra-population variables, such as socio-economic status, influence the selection forces that shape the life history are needed. Expand
Aging intervention, prevention, and therapy through hormesis.
- Medicine
- The journals of gerontology. Series A, Biological sciences and medical sciences
- 2004
Hormesis appears to be a promising and effective approach for modulating aging, for preventing or delaying the onset of age-related diseases, and for improving quality of life in old age. Expand
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine.
- Biology, Medicine
- Annual review of genetics
- 2005
The mitochondria provide a direct link between the authors' environment and their genes and the mtDNA variants that permitted their forbears to energetically adapt to their ancestral homes are influencing their health today. Expand
Understanding ageing.
- Medicine
- Philosophical transactions of the Royal Society of London. Series B, Biological sciences
- 1997
Although much future research will be needed to uncover the cellular and molecular changes which give rise to age-associated diseases, the major aim of such research is to devise procedures to delay or prevent the onset of these diseases. Expand
The Nature of Gerontogenes and Vitagenes: Antiaging Effects of Repeated Heat Shock on Human Fibroblasts
- Biology, Medicine
- Annals of the New York Academy of Sciences
- 1998
Experimental strategies through which this transmutation of vitagenes into virtual gerontogenes may be elucidated include induction of molecular damage, antisense intervention, and genetic screening for varied efficiencies of the members of the vitagene family. Expand
Aging is No Longer an Unsolved Problem in Biology
- Biology, Medicine
- Annals of the New York Academy of Sciences
- 2006
It is evident that the evolved design of many components of complex animals is incompatible with indefinite survival, which means that aging cannot be reversed, although it may be modulated, as, for example, by calorie restriction. Expand
Impairment of proteasome structure and function in aging.
- Biology, Medicine
- The international journal of biochemistry & cell biology
- 2002
It is now clear that proteasome activity is declining with age and that the loss in proteAsome activity during aging is dependent of at least three different mechanisms: decreased proteasomesome expression; alterations and/or replacement of prote asome subunits and formation of inhibitory cross-linked proteins. Expand