Theories of biological aging: Genes, proteins, and free radicals

  title={Theories of biological aging: Genes, proteins, and free radicals},
  author={Suresh I. S. Rattan},
  journal={Free Radical Research},
  pages={1230 - 1238}
  • S. Rattan
  • Published 1 January 2006
  • Biology
  • Free Radical Research
Traditional categorization of theories of aging into programmed and stochastic ones is outdated and obsolete. Biological aging is considered to occur mainly during the period of survival beyond the natural or essential lifespan (ELS) in Darwinian terms. Organisms survive to achieve ELS by virtue of genetically determined longevity assuring maintenance and repair systems (MRS). Aging at the molecular level is characterized by the progressive accumulation of molecular damage caused by… 

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