Theoretical study of near neutrality. I. Heterozygosity and rate of mutant substitution.

@article{Ohta1990TheoreticalSO,
  title={Theoretical study of near neutrality. I. Heterozygosity and rate of mutant substitution.},
  author={Tomoko Ohta and Hidenori Tachida},
  journal={Genetics},
  year={1990},
  volume={126 1},
  pages={
          219-29
        }
}
In order to clarify the nature of "near neutrality" in molecular evolution and polymorphism, extensive simulation studies were performed. Selection coefficients of new mutations are assumed to be small so that both random genetic drift and selection contribute to determining the behavior of mutants. The model also incorporates normally distributed spatial fluctuation of selection coefficients. If the system starts from "average neutrality," it will move to a better adapted state, and most new… CONTINUE READING
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