Theoretical studies on molecular determinants for recognition at H3 histamine receptors.

Abstract

The determinants for recognition at H3 histamine receptors are considered. Findings based on quantum-chemical calculations suggest that H3 histamine receptor is less hydrophilic than the H2. The form most likely to be recognized by the H3 receptor is an intramolecularly hydrogen-bonded form of alpha-methylhistamine. Receptor environment and hydration effects of active form of histamine analogs are of crucial importance.

Cite this paper

@article{Mazurek1994TheoreticalSO, title={Theoretical studies on molecular determinants for recognition at H3 histamine receptors.}, author={Aleksander P. Mazurek and Grazyna Karpińska}, journal={Zeitschrift für Naturforschung. C, Journal of biosciences}, year={1994}, volume={49 7-8}, pages={471-5} }