Theoretical studies of mechanisms and kinetic isotope effects on the decarboxylation of orotic acid and derivatives.

@article{Phillips2001TheoreticalSO,
  title={Theoretical studies of mechanisms and kinetic isotope effects on the decarboxylation of orotic acid and derivatives.},
  author={Linda M Phillips and Jason Ka-Wai Lee},
  journal={Journal of the American Chemical Society},
  year={2001},
  volume={123 48},
  pages={12067-73}
}
The mechanism of orotidine 5'-monophosphate decarboxylase was studied computationally by using the decarboxylation of orotic acid analogues as model systems. These calculations indicate that mechanisms involving proton transfer to the 2-oxygen or the 4-oxygen are energetically favorable, as compared to direct decarboxylation without proton transfer, for a… CONTINUE READING