Theoretical principles underlying optical stimulation of myelinated axons expressing channelrhodopsin-2.

@article{Arlow2013TheoreticalPU,
  title={Theoretical principles underlying optical stimulation of myelinated axons expressing channelrhodopsin-2.},
  author={Richard L. Arlow and Thomas J. Foutz and Cameron C. McIntyre},
  journal={Neuroscience},
  year={2013},
  volume={248},
  pages={
          541-51
        }
}
Numerous clinical conditions can be treated by neuromodulation of the peripheral nervous system (PNS). Typical electrical PNS therapies activate large diameter axons at lower electrical stimulus thresholds than small diameter axons. However, recent animal experiments with peripheral optogenetic neural stimulation (PONS) of myelinated axons expressing channelrhodopsin-2 (ChR2) have shown that this technique activates small diameter axons at lower irradiances than large diameter axons. We… CONTINUE READING
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