Theoretical modeling of masking DNA application in aptamer-facilitated biomarker discovery.

Abstract

In aptamer-facilitated biomarker discovery (AptaBiD), aptamers are selected from a library of random DNA (or RNA) sequences for their ability to specifically bind cell-surface biomarkers. The library is incubated with intact cells, and cell-bound DNA molecules are separated from those unbound and amplified by the polymerase chain reaction (PCR). The… (More)
DOI: 10.1021/ac400385v

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