Corpus ID: 35685786

Theoretical investigations on the structure and potential binding sites of antineoplaston A10 and experimental findings.

@article{Michalska1990TheoreticalIO,
  title={Theoretical investigations on the structure and potential binding sites of antineoplaston A10 and experimental findings.},
  author={Danuta Michalska},
  journal={Drugs under experimental and clinical research},
  year={1990},
  volume={16 7},
  pages={
          343-9
        }
}
  • D. Michalska
  • Published 1990
  • Chemistry, Medicine
  • Drugs under experimental and clinical research
The essential biological importance of antineoplastons has motivated the present theoretical and experimental studies on the structure and potential binding sites of Antineoplaston A10, 3-phenylacetylamino-2,6-piperidinedione. Semi-empirical molecular orbital calculations SCF-LCAO-MO were performed using the MNDO method. The calculated molecular geometry of A10 is in very good agreement with the recently obtained X-ray structure of synthetic A10. Experimental investigations of the Raman spectra… Expand
8 Citations
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Stability of antineoplaston A10 in aqueous solution
The analysis method and stability test of antineoplaston A10, a new anticancer drug candidate, were established. A10 and phenylacetyl- L-glutamine, one of the degradation products, can be detected byExpand
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Abstract FT-Raman and FT-IR spectra are reported for glutarimidato-Ag(I) and 3,3-dimethyl-glutarimidato-Ag(I) complexes, which show very close structural similarity to the corresponding Ag(I)Expand
FOURIER-TRANSFORM RAMAN AND INFRARED SPECTRA AND VIBRATIONAL ASSIGNMENT FOR SOLID GLUTARIMIDE
Abstract The FT-Raman and FT-IR spectra of crystalline glutarimide and its N-deuterated derivative have been recorded in the range 4000-100 cm−1. A complete vibrational assignment is given for allExpand