Theoretical investigation of the role of the RANK-RANKL-OPG system in bone remodeling.

  title={Theoretical investigation of the role of the RANK-RANKL-OPG system in bone remodeling.},
  author={Peter Pivonka and Jan Zimak and David W. Smith and Bruce S. Gardiner and Colin Robert Dunstan and Natalie A Sims and Thomas J Martin and Gregory R. Mundy},
  journal={Journal of theoretical biology},
  volume={262 2},
The RANK-RANKL-OPG system is an essential signaling pathway involved in bone cell-cell communication, with ample evidence that modification of the RANK-RANKL-OPG signaling pathway has major effects on bone remodeling. The first focus of this paper is to demonstrate that a theoretical model of bone cell-cell interactions is capable of qualitatively reproducing changes in bone associated with RANK-RANKL-OPG signaling. To do this we consider either biological experiments or bone diseases related… CONTINUE READING


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