Theoretical insight into the hydroxylamine oxidoreductase mechanism.

  title={Theoretical insight into the hydroxylamine oxidoreductase mechanism.},
  author={Mar{\'i}a Laura Fern{\'a}ndez and Dario A. Estrin and Sara E Bari},
  journal={Journal of inorganic biochemistry},
  volume={102 7},
The multiheme enzyme hydroxylamine oxidoreductase from the autotrophic bacteria Nitrosomonas europaea catalyzes the conversion of hydroxylamine to nitrite, with a complicate arrangement of heme groups in three subunits. As a distinctive feature, the protein has a covalent linkage between a tyrosyl residue of one subunit and a meso carbon atom of the heme active site of another. We studied the influence of this bond in the catalysis from a theoretical perspective through electronic structure… CONTINUE READING
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