Theoretical effects of transmembrane electroneutral exchange on membrane potential

@article{Jacob1984TheoreticalEO,
  title={Theoretical effects of transmembrane electroneutral exchange on membrane potential},
  author={Ralph Jacob and David R. Piwnica-Worms and C. Russell Horres and Melvyn Lieberman},
  journal={The Journal of General Physiology},
  year={1984},
  volume={83},
  pages={47 - 56}
}
Transmembrane electroneutral transport mechanisms [e.g., Na/H exchange, Cl/HCO3 exchange, (K + Cl) cotransport] have recently been identified in a wide variety of cell types. If these exchanges sum to give a net electroneutral Na/K exchange, they may hyperpolarize the membrane potential beyond the value calculated from the Mullins-Noda equation, provided the cell maintains steady state intracellular ionic concentrations. In extreme circumstances, the membrane potential could hyperpolarize… CONTINUE READING