Theoretical description of transdermal transport of hydrophilic permeants: application to low-frequency sonophoresis.

@article{Tang2001TheoreticalDO,
  title={Theoretical description of transdermal transport of hydrophilic permeants: application to low-frequency sonophoresis.},
  author={Hairong Tang and Samir Mitragotri and Daniel Blankschtein and Robert Langer},
  journal={Journal of pharmaceutical sciences},
  year={2001},
  volume={90 5},
  pages={545-68}
}
Application of ultrasound enhances transdermal transport of drugs (sonophoresis). The enhancement may result from enhanced diffusion due to ultrasound-induced skin alteration and/or from forced convection. To understand the relative roles played by these two mechanisms in low-frequency sonophoresis (LFS, 20 kHz), a theory describing the transdermal transport of hydrophilic permeants in both the absence and the presence of ultrasound was developed using fundamental equations of membrane… CONTINUE READING

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