Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies.

@article{Chou2006TheoreticalBE,
  title={Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies.},
  author={T C Chou},
  journal={Pharmacological reviews},
  year={2006},
  volume={58 3},
  pages={621-81}
}
  • T C Chou
  • Published 2006 in Pharmacological reviews
The median-effect equation derived from the mass-action law principle at equilibrium-steady state via mathematical induction and deduction for different reaction sequences and mechanisms and different types of inhibition has been shown to be the unified theory for the Michaelis-Menten equation, Hill equation, Henderson-Hasselbalch equation, and Scatchard… CONTINUE READING