Theoretical aspects of chiral separation in capillary electrophoresis. III. Application to beta-blockers.

@article{Wren1993TheoreticalAO,
  title={Theoretical aspects of chiral separation in capillary electrophoresis. III. Application to beta-blockers.},
  author={Stephen A C Wren and Randall C. Rowe},
  journal={Journal of chromatography},
  year={1993},
  volume={635 1},
  pages={113-8}
}
Enantiomers of the beta-blockers propranolol, atenolol, metoprolol, and oxprenolol have been separated by the addition of methyl-beta-cyclodextrin (MeBCD) to the operating buffer. There is an optimum concentration of MeBCD for separation for each of the beta-blockers, the magnitude of which could be ranked by the use of a mathematical model and log P data--an indication of the hydrophobicity of the molecule. 

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