Theoretical approach to explore the production routes of astatine radionuclides

  title={Theoretical approach to explore the production routes of astatine radionuclides},
  author={Moumita Maiti and Susanta Lahiri},
  journal={Physical Review C},
To fulfill the recent thrust of astatine radionuclides in the field of nuclear medicine, various production routes have been explored in the present work. The possible production routes of {sup 209-211}At comprise both light- and heavy-ion-induced reactions at the bombarding energy range starting from threshold to a maximum of 100 MeV. Excitation functions of those radionuclides, produced through various production routes, have been calculated by using nuclear reaction model codes TALYS… Expand
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Nuclear and chemical data for life sciences
  • M. Maiti
  • Chemistry
  • Journal of Radioanalytical and Nuclear Chemistry
  • 2013
Use of reactor produced radionuclides is popular in life sciences. However, cyclotron production of proton rich radionuclides are being more focused in recent times. These radionuclides have alreadyExpand
Separation of no-carrier-added astatine radionuclides from α-particle irradiated lead bismuth eutectic target: A classical method.
Possibility of separation of no-carrier-added (NCA) astatine radionuclides from the bulk lead-bismuth-eutectic (LBE) target was explored in a simple way in the laboratory scale. A LBE target wasExpand
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Accelerator production of the positron emitter zirconium-89
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Pre-equilibrium effects on proton, deuteron, and alpha induced reactions for the production of 72As as a PET imaging radioisotope
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Cyclotron isotopes and radiopharmaceuticals—XXXV astatine-211☆
Abstract The excitation functions for the 209Bi(α,2n)211At and 209Bi(α,3n)210At reactions were measured between 21.1 and 29.2 MeV. A target was designed to optimize the production of 211At withExpand
Assessing the 210At impurity in the production of 211At for radiotherapy by 210Po analysis via isotope dilution alpha spectrometry.
  • M. Schultz, M. Hammond, +6 authors M. Unterweger
  • Chemistry, Medicine
  • Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
  • 2006
A method for assessing the impurity 210At in cyclotron-produced 211At via isotope dilution alpha spectrometry is presented, which produces high-quality alpha spectra, with baseline alpha-peak resolution and chemical yields of greater than 85%. Expand
Evaluation of an internal cyclotron target for the production of 211At via the 209Bi (α,2n)211At reaction
Abstract Astatine-211 is a 7.2 h half-life α-emitting radionuclide which has shown great promise for targeted radiotherapy. It is generally produced by cyclotron bombardment of bismuth metal targetsExpand
Pre-equilibrium process in 3He-induced reactions on 59Co, 109Ag, 181Ta and 209Bi
Abstract Excitation functions and mean projected recoil-ion ranges of radioactive nuclei produced in the 3 He-induced reactions were measured for the targets of 59 Co, 109 Ag, 181 Ta and 209 Bi. MostExpand
Experimental study of the cross-sections of α-particle induced reactions on 209Bi
Abstract α- particle-induced nuclear reactions for generation of 211 At used in therapeutic nuclear medicine and possible contaminants were investigated with the stacked foil activation technique onExpand
Optimisation of cyclotron production parameters for the 209Bi(alpha, 2n) 211At reaction related to biomedical use of 211At.
  • G. Henriksen, S. Messelt, E. Olsen, R. Larsen
  • Materials Science, Medicine
  • Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
  • 2001
By using 29.1 MeV as a limit a large increase in EOB yield and sufficient radiochemical purity of extracted 211At were obtained and more cyclotrons could thereby deliver quantities useful for clinical cancer trials. Expand
Optimisation study of alpha-cyclotron production of At-211/Po-211g for high-LET metabolic radiotherapy purposes.
  • F. Groppi, M. Bonardi, +7 authors Z. Alfassi
  • Chemistry, Medicine
  • Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
  • 2005
The production of no-carrier-added (NCA) alpha-emitter (211)At/(211g)Po radionuclides for high-LET targeted radiotherapy and immunoradiotherapy, together with the required wet radiochemistry and radioanalytical quality controls carried out at LASA is described. Expand
Production and separation of Astatine Radionuclides: some new addition to Astatine Chemistry.
  • K. Roy, S. Lahiri
  • Chemistry, Medicine
  • Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
  • 2008
For the first time no-carrier-added (nca) (209,210)At radionuclides were produced by heavy ion ((7)Li) activation from 4 mg/cm(2) lead nitrate target. Astatine was separated from the bulk target byExpand
TALYS: Comprehensive Nuclear Reaction Modeling
TALYS is a nuclear‐reaction program which simulates nuclear reactions that involve neutrons, gamma‐rays, protons, deuterons, tritons, helions, and alpha‐particles, in the 1 keV – 200 MeV energyExpand
A new internal target system for production of (211)At on the cyclotron U-120M.
  • O. Lebeda, R. Jiran, J. Ráliš, J. Štursa
  • Chemistry, Medicine
  • Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
  • 2005
A new internal target system for astatine separation via dry distillation is designed and tested and the radionuclidic purity of (211)At acceptable for medical applications is found. Expand