Theoretical and experimental optimization of laser speckle contrast imaging for high specificity to brain microcirculation.

@article{Wang2007TheoreticalAE,
  title={Theoretical and experimental optimization of laser speckle contrast imaging for high specificity to brain microcirculation.},
  author={Zheng Guang Wang and Sarah Elizabeth Hughes and Sudath Dayasundara and Ravi Shankar. Menon},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2007},
  volume={27 2},
  pages={
          258-69
        }
}
The functional spatial resolution in most of hemodynamics-based functional neuroimaging techniques is limited by the fineness of hemodynamic control with the active vascular beds likely at submillimeter resolution. This study was designed to visualize changes of cerebral blood flow (CBF) at submillimeter spatial scale on the prolonged isoflurane-anesthetized rats model by using laser speckle contrast imaging (LSCI) technique. Recently, this old method has attracted an increasing interest in… CONTINUE READING
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