Theoretical and experimental comparisons of gene expression indexes for oligonucleotide arrays

@article{Lemon2002TheoreticalAE,
  title={Theoretical and experimental comparisons of gene expression indexes for oligonucleotide arrays},
  author={William J. Lemon and Jeffrey J. T. Palatini and Ralf Krahe and Fred A. Wright},
  journal={Bioinformatics},
  year={2002},
  volume={18 11},
  pages={1470-6}
}
MOTIVATION Oligonucleotide expression arrays exhibit systematic and reproducible variation produced by the multiple distinct probes used to represent a gene. Recently, a gene expression index has been proposed that explicitly models probe effects, and provides improved fits of hybridization intensity for arrays containing perfect match (PM) and mismatch (MM) probe pairs. RESULTS Here we use a combination of analytical arguments and empirical data to show directly that the estimates provided… CONTINUE READING