Theoretical and experimental characterization of 1,4-N⋯S σ-hole intramolecular interactions in bioactive N-acylhydrazone derivatives

@article{Pinheiro2018TheoreticalAE,
  title={Theoretical and experimental characterization of 1,4-N⋯S $\sigma$-hole intramolecular interactions in bioactive N-acylhydrazone derivatives},
  author={P. S. M. Pinheiro and D. A. Rodrigues and M. A. Alves and L. Tinoco and G. B. Ferreira and C. M. Sant’Anna and C. Fraga},
  journal={New Journal of Chemistry},
  year={2018},
  volume={42},
  pages={497-505}
}
Sigma-hole (σ-hole) bonds are interactions that are gaining special attention in medicinal chemistry. This type of interaction, initially assigned to the halogens (group 17 of the periodic table), has been extended to atoms of groups 14, 15 and 16. Sulfur atoms have been outstanding for describing these interactions at the intramolecular level (to induce conformational stability) and the intermolecular level (participating in molecular recognition of bioactive compounds by their respective… Expand
8 Citations
N-Acylhydrazones as drugs.

References

SHOWING 1-10 OF 55 REFERENCES
Halogen bonds in biological molecules.
Halogen bonding--a novel interaction for rational drug design?
A database study of nonbonded intramolecular sulfur-nucleophile contacts.
...
1
2
3
4
5
...