Theoretical analysis of the role of chromatin interactions in long-range action of enhancers and insulators.

  title={Theoretical analysis of the role of chromatin interactions in long-range action of enhancers and insulators.},
  author={Swagatam Mukhopadhyay and Paul Schedl and Vasily M. Studitsky and Anirvan M. Sengupta},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 50},
Long-distance regulatory interactions between enhancers and their target genes are commonplace in higher eukaryotes. Interposed boundaries or insulators are able to block these long-distance regulatory interactions. The mechanistic basis for insulator activity and how it relates to enhancer action-at-a-distance remains unclear. Here we explore the idea that topological loops could simultaneously account for regulatory interactions of distal enhancers and the insulating activity of boundary… CONTINUE READING
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