Theoretical analysis of the release of slowly dissolving drugs from spherical matrix systems.

@article{Frenning2004TheoreticalAO,
  title={Theoretical analysis of the release of slowly dissolving drugs from spherical matrix systems.},
  author={G{\"o}ran Frenning},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2004},
  volume={95 1},
  pages={109-17}
}
  • Göran Frenning
  • Published 2004 in
    Journal of controlled release : official journal…
Drug release from spherical matrix systems has been investigated theoretically, with numerical as well as analytical methods. The model used combines the Noyes-Whitney and diffusion equations, and thus takes the effects of a finite dissolution rate into account. The release profile has been determined numerically, by using well-established FORTRAN routines. An approximate analytical formula for the amount of released drug has been derived, which is valid during the early stages of the release… CONTINUE READING