Theoretical Flaws in the Gastric Emptying Breath Test: Why is it Dubious?

@article{Sanaka2005TheoreticalFI,
  title={Theoretical Flaws in the Gastric Emptying Breath Test: Why is it Dubious?},
  author={Masaki Sanaka and Takatsugu Yamamoto and Yasushi Kuyama},
  journal={Digestive Diseases and Sciences},
  year={2005},
  volume={50},
  pages={15-17}
}
To logically reply to these questions, precise kinetics of 13C in the human body should be recalled (Figure 1) (5). 13C-Octanoate is rapidly absorbed once it is emptied from the stomach. Then 13C-octanoate reaches the liver, where it undergoes preferential oxidation to CO2. Subsequently, CO2 appears in the systemic circulation, enters the pulmonary artery, and is exhaled quickly by the lung. As the rate of CO2 exhalation is regulated according to first-order kinetics (6), a certain portion of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Indirect vs direct assessment of gastric emptying: A randomized crossover trial comparing C-isotope breath analysis and MRI.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society • 2018

Effects of postgastric 13C-acetate processing on measurement of gastric emptying: a systematic investigation in health.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society • 2009

References

Publications referenced by this paper.
Showing 1-10 of 13 references

Gastric emptying flow curves separated from carbon-labeled octanoic acid breath test results.

The American journal of physiology • 1998
View 4 Excerpts
Highly Influenced

13C-octanoic acid breath test for gastric emptying measurement.

European journal of gastroenterology & hepatology • 2000
View 1 Excerpt

Methods for the assessment of gastric emptying in humans: an overview.

Diabetic medicine : a journal of the British Diabetic Association • 1996
View 3 Excerpts

Clinical Pharmacokinetics—Concepts and Applications

M Rowland, TN Tozer
1995
View 1 Excerpt