Theophylline tablets coated with aqueous latexes containing dispersed pore formers.

@article{Bodmeier1990TheophyllineTC,
  title={Theophylline tablets coated with aqueous latexes containing dispersed pore formers.},
  author={Roland A Bodmeier and Ornlaksana Paeratakul},
  journal={Journal of pharmaceutical sciences},
  year={1990},
  volume={79 10},
  pages={925-8}
}
Constant drug release was achieved from theophylline tablets coated with a multiporous membrane in an aqueous environment. The tablets were coated with an aqueous acrylic latex containing a dispersed pore-forming agent with pH-dependent solubility characteristics. The pore former, dibasic calcium phosphate, was insoluble in the latex but leached out rapidly in 0.1 M HCl. Theophylline was then released at a constant rate through the multiporous membrane. The drug release was a function of the… CONTINUE READING

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