Theophylline improves gas exchange during rest, exercise, and sleep in severe chronic obstructive pulmonary disease.

@article{Mulloy1993TheophyllineIG,
  title={Theophylline improves gas exchange during rest, exercise, and sleep in severe chronic obstructive pulmonary disease.},
  author={Eithne M. T. Mulloy and Walter T McNicholas},
  journal={The American review of respiratory disease},
  year={1993},
  volume={148 4 Pt 1},
  pages={
          1030-6
        }
}
The effects of theophylline on pulmonary function and gas exchange during rest, sleep, and exercise were assessed in 10 patients with severe but stable chronic obstructive pulmonary disease (COPD; median FEV1, 31% of predicted). The study was randomized, double blind, placebo controlled, and crossover in design, with each study period lasting 3 wk, and all other usual bronchodilator therapy was continued unchanged. All patients had detailed pulmonary function tests, in addition to exercise… CONTINUE READING
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