Theophylline colon specific tablets for chronotherapeutic treatment of nocturnal asthma.

@article{Yassin2012TheophyllineCS,
  title={Theophylline colon specific tablets for chronotherapeutic treatment of nocturnal asthma.},
  author={Alaa Eldeen Bakry Yassin and Alhassan H. Aodah and Saleh A Al-suwayeh and Ehab Ibrahim Taha},
  journal={Pharmaceutical development and technology},
  year={2012},
  volume={17 6},
  pages={
          712-8
        }
}
The ultimate goal is to design a new chronotherapeutic system for theophylline (TPH) with high potential benefits in treating nocturnal asthma. TPH core tablets were prepared by wet granulation using a developed formula. Compression coating over core tablets containing 200 mg TPH was done using granulated chitosan with 10% PVP K30. Different formulae F1, F2 and F3 were prepared using coat weights 260, 300 and 360 mg, respectively. The in vitro release characteristics in both variant pH media… CONTINUE READING
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