Theophylline antagonizes diazepam-induced psychomotor impairment

@article{Henauer1983TheophyllineAD,
  title={Theophylline antagonizes diazepam-induced psychomotor impairment},
  author={Stephan A. Henauer and Leo E. Hollister and Hamp K. Gillespie and Frances Moore},
  journal={European Journal of Clinical Pharmacology},
  year={1983},
  volume={25},
  pages={743-747}
}
Eight healthy men received an oral dose of 0.25 mg/kg diazepam followed 40 min later by an intravenous infusion of 100 ml physiological sodium chloride solution, with or without 4.4 mg/kg theophylline. Psychomotor function was assessed after each blood sampling up to 5 h post-infusion. Thirty min after diazepam psychomotor performance measured by Card Sorting test and Digit Symbol Substitution test was impaired and subjects felt sleepy and could think less clearly (two factors of the Clyde Mood… CONTINUE READING

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