Theophylline Restores Histone Deacetylase Activity and Steroid Responses in COPD Macrophages

@article{Cosio2004TheophyllineRH,
  title={Theophylline Restores Histone Deacetylase Activity and Steroid Responses in COPD Macrophages},
  author={Borja G Cosio and Loukia Tsaprouni and Kazuhiro Ito and Elen P I Jazrawi and Ian M. Adcock and Peter J Barnes},
  journal={The Journal of Experimental Medicine},
  year={2004},
  volume={200},
  pages={689 - 695}
}
Chronic obstructive pulmonary disease (COPD) is a common chronic inflammatory disease of the lungs with little or no response to glucocorticoids and a high level of oxidative stress. Histone deacetylase (HDAC) activity is reduced in cells of cigarette smokers, and low concentrations of theophylline can increase HDAC activity. We measured the effect of theophylline on HDAC activity and inflammatory gene expression in alveolar macrophages (AM) from patients with COPD. AM from normal smokers… CONTINUE READING
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