Theonellamide F, a Bicyclic Peptide Marine Toxin, Induces Formation of Vacuoles in 3Y1 Rat Embryonic Fibroblast

@article{Wada1999TheonellamideFA,
  title={Theonellamide F, a Bicyclic Peptide Marine Toxin, Induces Formation of Vacuoles in 3Y1 Rat Embryonic Fibroblast},
  author={S. Wada and S. Matsunaga and N. Fusetani and S. Watabe},
  journal={Marine Biotechnology},
  year={1999},
  volume={1},
  pages={337-341}
}
  • S. Wada, S. Matsunaga, +1 author S. Watabe
  • Published 1999
  • Biology, Medicine
  • Marine Biotechnology
    • Abstract: The effect of a marine bicyclic peptide, theonellamide F, on vacuole formation in exponentially growing 3Y1 rat embryonic fibroblasts was studied in comparison with the effect of monensin. Many abnormally large vacuoles appeared around the nucleus in the cells treated with 6 μM theonellamide F within 24 hours. Following prolonged treatment with this agent, the number of enlarged vacuoles increased. Such vacuoles accumulated many granules that showed Brownian movement. The effect of… CONTINUE READING
    View on Springer
    ncbi.nlm.nih.gov
    15 Citations
    Background Citations
    3

    Figures and Topics from this paper

    Figures

    Explore Further: Topics Discussed in This Paper

    15 Citations
    Citation Type

    Citation Type

    Interaction of Cytotoxic Bicyclic Peptides, Theonellamides A and F, with Glutamate Dehydrogenase and 17β-Hydroxysteroid Dehydrogenase IV
    • 8
    Sterol-dependent membrane association of the marine sponge-derived bicyclic peptide Theonellamide A as examined by 1H NMR.
    • 6
    • PDF
    Theonellamide A, a marine-sponge-derived bicyclic peptide, binds to cholesterol in aqueous DMSO: Solution NMR-based analysis of peptide-sterol interactions using hydroxylated sterol.
    • 2
    Interaction between the marine sponge cyclic peptide theonellamide A and sterols in lipid bilayers as viewed by surface plasmon resonance and solid-state (2)H nuclear magnetic resonance.
    • 33
    • PDF
    Targeting cholesterol in a liquid-disordered environment by theonellamides modulates cell membrane order and cell shape.
    • 13
    Synthesis of the Western Hemisphere of Theonellamide C
    Chemical diversity and mode of action of natural products targeting lipids in the eukaryotic cell membrane.
    • 3
    Bicyclic peptides: types, synthesis and applications.
    • 3
    Lewis acid facilitated regioselective synthesis of τ-histidinoalanine
    • 3
    Oxygenated Theonellastrols: Interpretation of Unusual Chemical Behaviors Using Quantum Mechanical Calculations and Stereochemical Reassignment of 7α-Hydroxytheonellasterol
    • PDF

    References

    SHOWING 1-10 OF 14 REFERENCES
    Actin-binding specificity of marine macrolide toxins, mycalolide B and kabiramide D.
    • 31
    Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity
    • 560
    • Highly Influential
    Golgi-disturbing agents
    • 341
    Theopalauamide, a Bicyclic Glycopeptide from Filamentous Bacterial Symbionts of the Lithistid Sponge Theonella swinhoei from Palau and Mozambique
    • 81
    Monovalent ionophores inhibit secretion of procollagen and fibronectin from cultured human fibroblasts.
    • 112
    • PDF
    Monovalent ionophores inhibit acetylcholinesterase release from cultured chick embryo skeletal muscle cells.
    • 42
    Rat cell line 3y1 and its virogenic polyoma‐ and SV40‐transformed derivatives
    • 263
    Cultured human fibroblasts in the study of atherosclerosis.
    • J. Avigan
    • Chemistry, Medicine
    • Advances in experimental medicine and biology
    • 1977
    • 11
    Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.
    • T. Mosmann
    • Biology, Medicine
    • Journal of immunological methods
    • 1983
    • 43,627
    • PDF
    Marine natural products.
    • 1,934