Theonellamide F, a Bicyclic Peptide Marine Toxin, Induces Formation of Vacuoles in 3Y1 Rat Embryonic Fibroblast

  title={Theonellamide F, a Bicyclic Peptide Marine Toxin, Induces Formation of Vacuoles in 3Y1 Rat Embryonic Fibroblast},
  author={S. Wada and S. Matsunaga and N. Fusetani and S. Watabe},
  journal={Marine Biotechnology},
  • S. Wada, S. Matsunaga, +1 author S. Watabe
  • Published 1999
  • Biology, Medicine
  • Marine Biotechnology
  • Abstract: The effect of a marine bicyclic peptide, theonellamide F, on vacuole formation in exponentially growing 3Y1 rat embryonic fibroblasts was studied in comparison with the effect of monensin. Many abnormally large vacuoles appeared around the nucleus in the cells treated with 6 μM theonellamide F within 24 hours. Following prolonged treatment with this agent, the number of enlarged vacuoles increased. Such vacuoles accumulated many granules that showed Brownian movement. The effect of… CONTINUE READING
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