Theobromine up-regulates cerebral brain-derived neurotrophic factor and facilitates motor learning in mice.

@article{Yoneda2017TheobromineUC,
  title={Theobromine up-regulates cerebral brain-derived neurotrophic factor and facilitates motor learning in mice.},
  author={Mitsugu Yoneda and Naotoshi Sugimoto and Masanori Katakura and Kentaro Matsuzaki and Hayate Tanigami and Akihiro Yachie and Takako Ohno-Shosaku and Osamu Shido},
  journal={The Journal of nutritional biochemistry},
  year={2017},
  volume={39},
  pages={
          110-116
        }
}
Theobromine, which is a caffeine derivative, is the primary methylxanthine produced by Theobroma cacao. Theobromine works as a phosphodiesterase (PDE) inhibitor to increase intracellular cyclic adenosine monophosphate (cAMP). cAMP activates the cAMP-response element-binding protein (CREB), which is involved in a large variety of brain processes, including the induction of the brain-derived neurotrophic factor (BDNF). BDNF supports cell survival and neuronal functions, including learning and… CONTINUE READING
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