Theobromine Upregulates Osteogenesis by Human Mesenchymal Stem Cells In Vitro and Accelerates Bone Development in Rats

Abstract

Theobromine (THB) is one of the major xanthine-like alkaloids found in cacao plant and a variety of other foodstuffs such as tea leaves, guarana and cola nuts. Historically, THB and its derivatives have been utilized to treat cardiac and circulatory disorders, drug-induced nephrotoxicity, proteinuria and as an immune-modulator. Our previous work… (More)
DOI: 10.1007/s00223-016-0215-6

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Cite this paper

@article{Clough2016TheobromineUO, title={Theobromine Upregulates Osteogenesis by Human Mesenchymal Stem Cells In Vitro and Accelerates Bone Development in Rats}, author={Bret H. Clough and Joni H. Ylostalo and Elizabeth J Browder and Eoin P. McNeill and Thomas J. Bartosh and Henry Ralph Rawls and Tetsuo Nakamoto and Carl A. Gregory}, journal={Calcified Tissue International}, year={2016}, volume={100}, pages={298-310} }