• Corpus ID: 25922465

Theobroma cacao: Review of the Extraction, Isolation, and Bioassay of Its Potential Anti-cancer Compounds.

  title={Theobroma cacao: Review of the Extraction, Isolation, and Bioassay of Its Potential Anti-cancer Compounds.},
  author={Zainal Baharum and Abdah Md Akim and Taufiq-Yap Yun Hin and Roslida Abdul Hamid and Rosmin Kasran},
  journal={Tropical life sciences research},
  volume={27 1},
Plants have been a good source of therapeutic agents for thousands of years; an impressive number of modern drugs used for treating human diseases are derived from natural sources. The Theobroma cacao tree, or cocoa, has recently garnered increasing attention and become the subject of research due to its antioxidant properties, which are related to potential anti-cancer effects. In the past few years, identifying and developing active compounds or extracts from the cocoa bean that might exert… 

Tables from this paper

Chemical characteristics of non-edible cocoa plant (Theobroma cacao L.) parts and their antiproliferative activity against various cancer cell lines

Plants have been a good source of therapeutic agents for thousands of years and an impressive number of modern drugs used for treating cancer diseases are derived from natural sources. Due to its

Benefits of Theobroma cacao and Its Phytocompounds as Cosmeceuticals

In this chapter, the cosmeceutical efficiency of T. cacao along with its other dermal therapeutic potentials is focused and analyzedAlong with its molecular mechanisms.

In vitro anthelmintic and antioxidant activities of the leaf extracts of Theobroma cacao L.

Theobroma cacao L. (Sterculiaceae) leaves have been used in folklore medicine as treatment for wound healing, worm expellers and malaria cure. In this study, the antioxidant and anthelmintic

Effect of Theobroma cacao L. on the Efficacy and Toxicity of Doxorubicin in Mice Bearing Ehrlich Ascites Carcinoma

The cocoa bean extract (COE) acted against doxorubicin-induced organ toxicity; potent antioxidant and anticancer activities were also reflected by the COE itself, and may serve as an adjuvant nutraceutical in cancer chemotherapy.

Related Pentacyclic Triterpenes Have Immunomodulatory Activity in Chronic Experimental Visceral Leishmaniasis

This is the first comparative work showing the in vitro activity, toxicity, and therapeutic activity of Lu and UA in the chronic model of visceral leishmaniasis caused by L. (L.) infantum; additionally, both triterpenes activated cellular immune response in the hamster model of abdominal leish maniasis.


The findings infer that the potential bioactive compound of this plant was effective against colon cancer and acquire anticancer activity.

Nutraceutical-prophylactic and Therapeutic Role of Functional Food inHealth

The research work to understand the relationship between different beneficial foods and human health system and to explore the role of the functional foods against various diseases will be an important aspect scientifically, clinically as well as socio-economically.

Potensi Ekstrak Biji Coklat (Theobroma cacao Linn) sebagai Inhibitor Tirosinase untuk Produk Pencerah Kulit

Hyperpigmentation is a condition of excessive skin pigments production. The skin colour is strongly influenced by the presence of melanin that marked by the melanin tyrosinase enzyme activity. Cocoa



Anticancer Agents from Non-Edible Parts of Theobroma cacao

The results revealed that the cocoa leaf extract presented the highest antiproliferative activity against breast cancer cell line (MCF-7) with IC50 value was 41.43 ± 3.26 μg/ml and was selected for further purification using bioassay guided fractionation.

Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer Properties

The anticancer effects of phenolics in-vitro and in- vivo animal models are viewed, including recent human intervention studies, and possible mechanisms of action involving antioxidant and pro-oxidant activity as well as interference with cellular functions are discussed.

Bioactivity-guided isolation of antiproliferative compounds from Centaurea jacea L.

Plant Secondary Metabolites as Potential Anticancer Agents and Cancer Chemopreventives

Recent examples of bioactive compounds obtained in the author’slaboratory in projects directed towards the search for novel anticancer agents and cancer chemopre-ventives from higher plants will be presented.

Extraction, isolation and characterization of bioactive compounds from plants' extracts.

The analysis of bioactive compounds present in the plant extracts involving the applications of common phytochemical screening assays, chromatographic techniques such as HPLC and, TLC as well as non-chromatographic Techniques such as immunoassay and Fourier Transform Infra Red (FTIR) are discussed.