• Published 2009

Themis controls thymocyte selection through regulation of T cell antigen receptor – mediated signaling

@inproceedings{Fu2009ThemisCT,
  title={Themis controls thymocyte selection through regulation of T cell antigen receptor – mediated signaling},
  author={Guo Fu and S{\'e}bastien Vall{\'e}e and Vasily Rybakin and Marielena V. McGuire and Jeanette Ampudia and Claudia Brockmeyer and Mogjiborahman Salek and Paul R Fallen and John A.H. Hoerter and Anil Munshi and Yina H Huang and Jianfang Hu and Howard S. Fox and Karsten Sauer and Oreste Acuto and Nicholas R J Gascoigne},
  year={2009}
}
Themis (thymocyte-expressed molecule involved in selection), a member of a family of proteins with unknown functions, is highly conserved among vertebrates. Here we found that Themis had high expression in thymocytes between the pre–T cell antigen receptor (pre-TCR) and positive-selection checkpoints and low expression in mature T cells. Themis-deficient thymocytes showed defective positive selection, which resulted in fewer mature thymocytes. Negative selection was also impaired in Themis… CONTINUE READING

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The Function of Themis2 in B Cells

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GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.

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Thymic-specific regulation of TCR signaling by Tespa1

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