Themes and variations on ubiquitylation.

  title={Themes and variations on ubiquitylation.},
  author={Allan M. Weissman},
  journal={Nature reviews. Molecular cell biology},
  volume={2 3},
Ubiquitylation--the conjugation of proteins with a small protein called ubiquitin--touches upon all aspects of eukaryotic biology, and its defective regulation is manifest in diseases that range from developmental abnormalities and autoimmunity to neurodegenerative diseases and cancer. A few years ago, we could only have dreamt of the complex arsenal of enzymes dedicated to ubiquitylation. Why has nature come up with so many ways of doing what seems to be such a simple job? 
Highly Influential
This paper has highly influenced 28 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
457 Citations
121 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 457 extracted citations


Publications referenced by this paper.
Showing 1-10 of 121 references

Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasomedependent processing

  • T Hoppe
  • Cell 102,
  • 2000

Activation of the I κ B kinase complex by TRAF 6 requires a dimeric ubiquitinconjugating enzyme complex and a unique polyubiquitin chain

  • L. Deng
  • Cell
  • 2000

Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin

  • L Deng
  • chain. Cell 103,
  • 2000

Similar Papers

Loading similar papers…