Thematic review series: lipid posttranslational modifications. CAAX modification and membrane targeting of Ras.

@article{Wright2006ThematicRS,
  title={Thematic review series: lipid posttranslational modifications. CAAX modification and membrane targeting of Ras.},
  author={Latasha P Wright and Mark R Philips},
  journal={Journal of lipid research},
  year={2006},
  volume={47 5},
  pages={883-91}
}
Proteins that terminate with a consensus sequence known as CAAX undergo a series of posttranslational modifications that include polyisoprenylation, endoproteolysis, and carboxyl methylation. These modifications render otherwise hydrophilic proteins hydrophobic at their C termini such that they associate with membranes. Whereas prenylation occurs in the cytosol, postprenylation processing is accomplished on the cytoplasmic surface of the endoplasmic reticulum and Golgi apparatus. Among the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 96 extracted citations

Connexin32 mutations cause loss of function in Schwann cells and oligodendrocytes leading to PNS and CNS myelination defects.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2009
View 9 Excerpts
Highly Influenced

Biogenesis of the Saccharomyces cerevisiae pheromone a-factor, from yeast mating to human disease.

Microbiology and molecular biology reviews : MMBR • 2012
View 4 Excerpts
Highly Influenced

Efforts to Develop KRAS Inhibitors.

Cold Spring Harbor perspectives in medicine • 2018

Similar Papers

Loading similar papers…