Theaflavins enhance intestinal barrier of Caco-2 Cell monolayers through the expression of AMP-activated protein kinase-mediated Occludin, Claudin-1, and ZO-1

@article{Park2015TheaflavinsEI,
  title={Theaflavins enhance intestinal barrier of Caco-2 Cell monolayers through the expression of AMP-activated protein kinase-mediated Occludin, Claudin-1, and ZO-1},
  author={Ha-Young Park and Y. Kunitake and N. Hirasaki and Mitsuru Tanaka and T. Matsui},
  journal={Bioscience, Biotechnology, and Biochemistry},
  year={2015},
  volume={79},
  pages={130 - 137}
}
We investigated the effect of theaflavins (TFs) on membrane barrier of Caco-2 cells. For fluorescein-transport experiments, the apparent permeability (Papp) of fluorescein in Caco-2 cells pretreated with 20 μM TFs were significantly decreased compared with that in untreated cells. Although the respective monomeric catechins did not show any Papp reduction, purpurogallin pretreatment resulted in a significant Papp reduction similar to that of TF-3′-O-gallate (TF3′G) pretreatment. This indicates… Expand
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Objective : In the small intestine, peptide transporter 1 (PEPT1) plays a role in the transport of di- and tri-peptides. Recently, we found that theaflavins (TFs), dimeric catechins, inhibited theExpand
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