TheMg 2 + andMg 2 +-Nucleotide-Regulated Channel-Kinase TRPM 7

  title={TheMg 2 + andMg 2 +-Nucleotide-Regulated Channel-Kinase TRPM 7},
  author={Reinhold Penner and Arthur Fleig},
TRPM7 is a member of the melastatin-related subfamily of TRP channels and represents a protein that contains both an ion channel and a kinase domain. The protein is ubiquitously expressed and represents the only ion channel known that is essential for cellular viability. TRPM7 is a divalent cation-selective ion channel that is permeable to Ca2+ and Mg2+, but also conducts essential metals such as Zn2+, Mn2+, and Co2+, as well as nonphysiologic or toxic metals such as Ni2+, Cd2+, Ba2+, and Sr2… CONTINUE READING
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