The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes

@article{Sakaguchi2010TheZP,
  title={The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes},
  author={Shinya Sakaguchi and Matthias Hombauer and Ivan Bili{\'c} and Yoshinori Naoe and Alexandra Schebesta and Ichiro Taniuchi and Wilfried Ellmeier},
  journal={Nature Immunology},
  year={2010},
  volume={11},
  pages={442-448}
}
The CD4 versus CD8 lineage specification of thymocytes is linked to coreceptor expression. The transcription factor MAZR has been identified as an important regulator of Cd8 expression. Here we show that variegated CD8 expression by loss of Cd8 enhancers was reverted in MAZR-deficient mice, which confirms that MAZR negatively regulates the Cd8 loci during the transition to the double-positive (DP) stage. Moreover, loss of MAZR led to partial redirection of major histocompatibility complex (MHC… CONTINUE READING