The zinc binding receptor GPR39 interacts with 5-HT1A and GalR1 to form dynamic heteroreceptor complexes with signaling diversity.

@article{TenaCampos2015TheZB,
  title={The zinc binding receptor GPR39 interacts with 5-HT1A and GalR1 to form dynamic heteroreceptor complexes with signaling diversity.},
  author={Merc{\`e} Tena-Campos and Eva Ramon and Dasiel O Borroto-Escuela and Kjell Fuxe and Pere Garriga},
  journal={Biochimica et biophysica acta},
  year={2015},
  volume={1852 12},
  pages={
          2585-92
        }
}
GPR39 is a class A G protein-coupled receptor involved in zinc binding and glucose homeostasis regulation, among other physiological processes. GPR39 was originally thought to be the receptor for obestatin peptide but this view has been challenged. However, activation of this receptor by zinc has been clearly established. Recent studies suggest that low GPR39 expression, due to deficient zinc levels, is involved in major depressive disorder. We have previously reported that zinc can alter… CONTINUE READING

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