The zic1 gene is an activator of Wnt signaling.

@article{Merzdorf2006TheZG,
  title={The zic1 gene is an activator of Wnt signaling.},
  author={Christa S Merzdorf and Hazel L. Sive},
  journal={The International journal of developmental biology},
  year={2006},
  volume={50 7},
  pages={611-7}
}
The zic1 gene plays an important role in early patterning of the Xenopus neurectoderm. While Zic1 does not act as a neural inducer, it synergizes with the neural inducing factor Noggin to activate expression of posterior neural genes, including the midbrain/hindbrain boundary marker engrailed-2. Since the Drosophila homologue of zic1, odd-paired (opa), regulates expression of the wingless and engrailed genes and since Wnt proteins posteriorize neural tissue in Xenopus, we asked whether Xenopus… CONTINUE READING

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