The zebrafish young mutation acts non-cell-autonomously to uncouple differentiation from specification for all retinal cells.

@article{Link2000TheZY,
  title={The zebrafish young mutation acts non-cell-autonomously to uncouple differentiation from specification for all retinal cells.},
  author={Brian A. Link and James M. Fadool and Jarema J Malicki and John E. Dowling},
  journal={Development},
  year={2000},
  volume={127 10},
  pages={2177-88}
}
Embryos from mutagenized zebrafish were screened for disruptions in retinal lamination to identify factors involved in vertebrate retinal cell specification and differentiation. Two alleles of a recessive mutation, young, were isolated in which final differentiation and normal lamination of retinal cells were blocked. Early aspects of retinogenesis including the specification of cells along the inner optic cup as retinal tissue, polarity of the retinal neuroepithelium, and confinement of cell… CONTINUE READING