The zebrafish pob gene encodes a novel protein required for survival of red cone photoreceptor cells.

  title={The zebrafish pob gene encodes a novel protein required for survival of red cone photoreceptor cells.},
  author={Michael R. Taylor and Satoshi Kikkawa and Antonio D{\'i}ez-Juan and Visvanathan Ramamurthy and Koichi Kawakami and Peter Carmeliet and Susan E Brockerhoff},
  volume={170 1},
The zebrafish mutant, partial optokinetic response b (pob), was isolated using an N-ethyl N-nitrosourea (ENU)-based screening strategy designed to identify larvae with defective optokinetic responses in red but not white light. Previous studies showed that red-light blindness in pob is due to the specific loss of long-wavelength photoreceptor cells via an apoptotic mechanism. Here, we used positional cloning to identify the mutated pob gene. We find that pob encodes a highly conserved 30-kDa… CONTINUE READING


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