Characterization of the murine hoxd4 and hox-associated miR-10b transcripts.
It is suggested that within the context of a youth-services agency such as this, where children are at risk of exploitation and/or abuse, the use of these services is a good idea and should be considered.
An atlas of seven zebrafish hox cluster mutants provides insights into sub/neofunctionalization of vertebrate Hox clusters.
This study isolated all of the seven hox cluster loss-of-function alleles in zebrafish using the CRISPR-Cas9 system and provides insights into discrete sub/neofunctionalization of vertebrate Hox clusters after quadruplication of the ancient Hox cluster.
Evolution after Whole-Genome Duplication: Teleost MicroRNAs
- MedicineMolecular biology and evolution
This study provides the first genome-wide, multispecies analysis of the mechanisms influencing metazoan miRNA evolution after whole-genome duplication, and reveals both conserved and divergent expression patterns across species in line with miRNA functions in phenotypic canalization and diversification.
A zebrafish hox gene acts before gastrulation to specify the hemangioblast
- Medicine, BiologyGenesis
Both DNA binding and interaction with cofactor Pbx were further shown to be required for rescue of the morphant phenotype, defining a pre‐gastrulation role for Hoxd4a, the earliest developmental function of a vertebrate Hox gene so far described.
The sterlet sturgeon genome sequence and the mechanisms of segmental rediploidization
- Medicine, BiologyNature Ecology & Evolution
A genome assembly of the sterlet, Acipenser ruthenus, reveals a whole-genome duplication early in the evolution of the entire sturgeon lineage and provides details about the rediploidization of the genome.
Comparative genomic approaches to unravel the evolutionary mechanisms of cichlid fishes
This document summarizes current capabilities, research and operational priorities, and plans for further studies that were established at the 2015 USGS workshop on quantitative hazard assessments of earthquake-triggered landsliding and liquefaction in the Central American region.
MicroRNA gene regulation in extremely young and parallel adaptive radiations of crater lake cichlid fish.
- Medicine, BiologyMolecular biology and evolution
Investigating the post-transcriptional regulatory role of miRNAs in the repeated sympatric divergence of Midas cichlid fishes provides support for the hypothesis that extremely quickly evolving miRNA regulation can contribute to rapid evolutionary divergence even in the presence of gene flow.
INVESTIGATING THE GENE REGULATORY NETWORK UNDERLYING CAUDAL HINDBRAIN SPECIFICATION IN EMBRYONIC ZEBRAFISH
This chapter discusses the development of the vertebrate hindbrain and the historical model describing the caudal hindbrain (r4-6) gene regulatory network in zebrafish.
Regulatory landscape of the Hox transcriptome.
- Biology, MedicineThe International journal of developmental biology
Current knowledge is discussed of how the different layers of post-transcriptional regulation and the production of a variety of noncoding RNA species control Hox output, and how this shapes formation of developmental systems that are reproducibly patterned by complex Hox networks.
SHOWING 1-10 OF 11 REFERENCES
miRBase: microRNA sequences, targets and gene nomenclature
- Biology, Computer ScienceNucleic Acids Res.
The miRBase database aims to provide integrated interfaces to comprehensive microRNA sequence data, annotation and predicted gene targets, and acts as an independent arbiter of microRNA gene nomenclature.
A whole lotta jumpin' goin' on: new transposon tools for vertebrate functional genomics.
- Biology, MedicineTrends in genetics : TIG
Two recent articles report on the construction of retrotransposable elements that efficiently 'jump' in mammalian cells that hold great promise as useful vectors for insertional mutagenesis screens in the mouse.
Hox clusters as models for vertebrate genome evolution.
- Biology, MedicineTrends in genetics : TIG
The surprising variation in the number of Hox clusters and the genomic architecture within vertebrate lineages, especially within the ray-finned fish, reflects a history of duplications and…
In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes
- Biology, MedicineNature Methods
A detailed analysis of conditions for in situ detection of miRNAs in the zebrafish embryo using locked nucleic acid (LNA)-modified DNA probes is performed and expression patterns for 15 miRNA molecules in the mouse embryo are reported.
The developmental miRNA profiles of zebrafish as determined by small RNA cloning.
- Biology, MedicineGenes & development
It is revealed that the zygotes are essentially devoid of miRNAs and that their expression begins during the blastula period with a zebrafish-specific family of mi RNAs encoded by closely spaced multicopy genes.
The genesis and evolution of homeobox gene clusters
- Biology, MedicineNature Reviews Genetics
Comparative genomics studies indicate that the more recently discovered ParaHox and NK clusters were linked to the Hox cluster early in evolution, and that together they constituted a 'megacluster' of homeobox genes that conspicuously contributed to body-plan evolution.
A Global Control Region Defines a Chromosomal Regulatory Landscape Containing the HoxD Cluster
- Biology, MedicineCell
A targeted enhancer-trap approach was used to identify a DNA segment capable of directing reporter gene expression in both digits and CNS, following Lnp, Evx2, and Hoxd-specific patterns, and discusses the heuristic value of these results in term of locus specific versus gene-specific regulation.
Hox cluster duplications and the opportunity for evolutionary novelties
- Biology, MedicineProceedings of the National Academy of Sciences of the United States of America
It is proposed that the constraints on vertebrate Hox cluster structure lead to an association between the retention of duplicated Hox clusters and adaptive radiations, which opens a window of evolvability for the H Cox clusters.
New microRNAs from mouse and human.
- Biology, MedicineRNA
31 novel miRNAs are described that were identified by cloning from mouse tissues and the human Saos-2 cell line and are important for assisting bioinformatics target mRNA identification and comprehensive genome annotation.