The zebrafish eye—a paradigm for investigating human ocular genetics

@article{Richardson2017TheZE,
  title={The zebrafish eye—a paradigm for investigating human ocular genetics},
  author={Rose Richardson and Dhani Tracey-White and Alexandre Webster and Mariya Moosajee},
  journal={Eye},
  year={2017},
  volume={31},
  pages={68-86}
}
Although human epidemiological and genetic studies are essential to elucidate the aetiology of normal and aberrant ocular development, animal models have provided us with an understanding of the pathogenesis of multiple developmental ocular malformations. Zebrafish eye development displays in depth molecular complexity and stringent spatiotemporal regulation that incorporates developmental contributions of the surface ectoderm, neuroectoderm and head mesenchyme, similar to that seen in humans… CONTINUE READING
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