The zebrafish as a tool for understanding the biology of visual disorders.

@article{Goldsmith2003TheZA,
  title={The zebrafish as a tool for understanding the biology of visual disorders.},
  author={Paul Goldsmith and William A. Harris},
  journal={Seminars in cell & developmental biology},
  year={2003},
  volume={14 1},
  pages={11-8}
}
Retinal degenerations are the commonest cause of blindness in the Western world, affecting 5% of the population, yet remain largely untreatable. A better understanding of the mechanisms of disease is needed. Zebrafish fill a gap in the current repertoire of models, offering genetic tractability in a vertebrate. Their retina has many similarities with a human retina. Importantly, unlike rodents, they have rich colour vision, offering the potential to model the macular degenerations. A variety of… CONTINUE READING