The zalpha domain of the editing enzyme dsRNA adenosine deaminase binds left-handed Z-RNA as well as Z-DNA.

@article{Brown2000TheZD,
  title={The zalpha domain of the editing enzyme dsRNA adenosine deaminase binds left-handed Z-RNA as well as Z-DNA.},
  author={Bernard Andrew Brown and Ky Lowenhaupt and Christina M Wilbert and Eugene B. Hanlon and A. Rich},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 25},
  pages={13532-6}
}
The Zalpha domain of human double-stranded RNA adenosine deaminase 1 binds specifically to left-handed Z-DNA and stabilizes the Z-conformation. Here we report spectroscopic and analytical results that demonstrate that Zalpha can also stabilize the left-handed Z-conformation in double-stranded RNA. Zalpha induces a slow transition from the right-handed A-conformation to the Z-form in duplex r(CG)(6), with an activation energy of 38 kcal mol(-1). We conclude that Z-RNA as well as Z-DNA can be… CONTINUE READING

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