The yin and yang of regulatory T cells and inflammation in RA

@article{Notley2010TheYA,
  title={The yin and yang of regulatory T cells and inflammation in RA},
  author={Clare A. Notley and Michael R. Ehrenstein},
  journal={Nature Reviews Rheumatology},
  year={2010},
  volume={6},
  pages={572-577}
}
Rheumatoid arthritis (RA) is characterized by chronic inflammation leading to joint destruction. Regulatory T (TREG) cells are potent suppressors of autoimmunity, but are not capable of controlling every aspect of the inflammatory reaction. We have found that TREG-cell function is abnormal in patients with RA, and that a distinct population of TREG cells with potent suppressive properties is induced after therapy with inhibitors of tumor necrosis factor. In this Review, we discuss the mutual… CONTINUE READING

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