The yin and yang of kidney development and Wilms' tumors.

  title={The yin and yang of kidney development and Wilms' tumors.},
  author={Peter Hohenstein and Kathy Pritchard-Jones and Jocelyn Charlton},
  journal={Genes & development},
  volume={29 5},
Wilms' tumor, or nephroblastoma, is the most common pediatric renal cancer. The tumors morphologically resemble embryonic kidneys with a disrupted architecture and are associated with undifferentiated metanephric precursors. Here, we discuss genetic and epigenetic findings in Wilms' tumor in the context of renal development. Many of the genes implicated in Wilms' tumorigenesis are involved in the control of nephron progenitors or the microRNA (miRNA) processing pathway. Whereas the first group… CONTINUE READING
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