The yin and yang of B cells in graft rejection and tolerance.

  title={The yin and yang of B cells in graft rejection and tolerance.},
  author={Valeriya Zarkhin and Geetha Chalasani and Minnie M. Sarwal},
  journal={Transplantation reviews},
  volume={24 2},
Various lineages of B cells are being increasingly recognized as important players in the etiology and prognosis of both acute and chronic graft rejection. The role of immature, chronically activated B cells, as efficient antigen-presenting cells, supporting recalcitrant cell-mediated graft rejection and late lineage B cells driving humoral rejections, is being increasingly recognized. This review captures the recent literature on this subject and discusses the various roles of the B cell in… CONTINUE READING

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