The yield, processing, and biological consequences of clustered DNA damage induced by ionizing radiation.

@article{Shikazono2009TheYP,
  title={The yield, processing, and biological consequences of clustered DNA damage induced by ionizing radiation.},
  author={Naoya Shikazono and Miho Noguchi and Kentaro Fujii and Ayumi Urushibara and Akinari Yokoya},
  journal={Journal of radiation research},
  year={2009},
  volume={50 1},
  pages={27-36}
}
After living cells are exposed to ionizing radiation, a variety of chemical modifications of DNA are induced either directly by ionization of DNA or indirectly through interactions with water-derived radicals. The DNA lesions include single strand breaks (SSB), base lesions, sugar damage, and apurinic/apyrimidinic sites (AP sites). Clustered DNA damage, which is defined as two or more of such lesions within one to two helical turns of DNA induced by a single radiation track, is considered to be… CONTINUE READING

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