The yefM-yoeB toxin-antitoxin systems of Escherichia coli and Streptococcus pneumoniae: functional and structural correlation.

@article{Nieto2007TheYT,
  title={The yefM-yoeB toxin-antitoxin systems of Escherichia coli and Streptococcus pneumoniae: functional and structural correlation.},
  author={Concepci{\'o}n Varela Nieto and Izhack Cherny and Seok Kooi Khoo and Mario Garc{\'i}a de Lacoba and Wai Ting Chan and Chew Chieng Yeo and Ehud Gazit and Manuel Espinosa},
  journal={Journal of bacteriology},
  year={2007},
  volume={189 4},
  pages={
          1266-78
        }
}
Toxin-antitoxin loci belonging to the yefM-yoeB family are located in the chromosome or in some plasmids of several bacteria. We cloned the yefM-yoeB locus of Streptococcus pneumoniae, and these genes encode bona fide antitoxin (YefM(Spn)) and toxin (YoeB(Spn)) products. We showed that overproduction of YoeB(Spn) is toxic to Escherichia coli cells, leading to severe inhibition of cell growth and to a reduction in cell viability; this toxicity was more pronounced in an E. coli B strain than in… CONTINUE READING
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Toxin-antitoxin genes of the Gram-positive pathogen Streptococcus pneumoniae: so few and yet so many.

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  • 2012
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Genetic regulation of the yefM-yoeB toxin-antitoxin locus of Streptococcus pneumoniae.

  • Journal of bacteriology
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