The yeast putative transcriptional repressor RGM1 is a proline-rich zinc finger protein.

@article{Estruch1991TheYP,
  title={The yeast putative transcriptional repressor RGM1 is a proline-rich zinc finger protein.},
  author={Francisco Estruch},
  journal={Nucleic acids research},
  year={1991},
  volume={19 18},
  pages={4873-7}
}
I have cloned a yeast gene, RGM1, which encodes a proline-rich zinc, finger protein. rgm1 mutants do not show any obvious phenotype but overexpression of RGM1 gene greatly impairs cell growth. The proline-rich region of RGM1 attached to a heterologous DNA binding domain is able to repress the expression of the target gene. RGM1 shares similar zinc finger motifs with the mammalian Egr (early growth response) proteins as well as proline-rich sequences with a high serine and threonine content… CONTINUE READING

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